For more general boolean functions that you would like to use as a filter and that depend on more than one column, you can use:
df = df[df[['col_1','col_2']].apply(lambda x: f(*x), axis=1)]
where f is a function that is applied to every pair of elements (x1, x2) from col_1 and col_2 and returns True or False depending on any condition you want on (x1, x2).