The reason why you have to modify the AppData could be:
Even after doing that, the latest LTE (4.4.4) still have problem with Windows 10, it worked for a little while then whenever I try to:
$ npm install _some_package_ --global
Node throw the "FATAL ERROR CALL_AND_RETRY_LAST Allocation failed - process out of memory" error. Still try to find a solution to that problem.
The only thing I find works is to run Vagrant or Virtual box, then run the Linux command line (must matching the path) which is quite a messy solution.