Multi-threading with javascript is clearly possible using webworkers bring by HTML5.
Main difference between webworkers and a standard multi-threading environment is memory resources are not shared with the main thread, a reference to an object is not visible from one thread to another. Threads communicate by exchanging messages, it is therefore possible to implement a synchronzization and concurrent method call algorithm following an event-driven design pattern.
Many frameworks exists allowing to structure programmation between threads, among them OODK-JS, an OOP js framework supporting concurrent programming https://github.com/GOMServices/oodk-js-oop-for-js