Sorry to post on such an old thread, but I tried several of the tips here, and none of them worked for me.
It's slightly different than a text editor, but I found that Beyond Compare could handle an extremely large (3.6 Gig) file on my Vista 32-bit machine.
This is a file that that Emacs, Large Text File Viewer, HexEdit, and Notepad++ all choked on.
-Eric