[python] How can I quantify difference between two images?

Check out how Haar Wavelets are implemented by isk-daemon. You could use it's imgdb C++ code to calculate the difference between images on-the-fly:

isk-daemon is an open source database server capable of adding content-based (visual) image searching to any image related website or software.

This technology allows users of any image-related website or software to sketch on a widget which image they want to find and have the website reply to them the most similar images or simply request for more similar photos at each image detail page.