[c] How can you flush a write using a file descriptor?

You have two choices:

  1. Use fileno() to obtain the file descriptor associated with the stdio stream pointer

  2. Don't use <stdio.h> at all, that way you don't need to worry about flush either - all writes will go to the device immediately, and for character devices the write() call won't even return until the lower-level IO has completed (in theory).

For device-level IO I'd say it's pretty unusual to use stdio. I'd strongly recommend using the lower-level open(), read() and write() functions instead (based on your later reply):

int fd = open("/dev/i2c", O_RDWR);
ioctl(fd, IOCTL_COMMAND, args);
write(fd, buf, length);

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How can you flush a write using a file descriptor?