I remember reading about one guy who would put his multi-line comments into a triple-quoted variable:
x = '''
This is my
super-long mega-comment.
Wow there are a lot of lines
going on here!
'''
This does take up a bit of memory, but it gives you multi-line comment functionality, and plus most editors will highlight the syntax for you :)
It's also easy to comment out code by simply wrapping it with
x = '''
and
'''