[.net] What does the Visual Studio "Any CPU" target mean?

I think most of the important stuff has been said, but I just thought I'd add one thing: If you compile as Any CPU and run on an x64 platform, then you won't be able to load 32-bit DLL files, because your application wasn't started in WoW64, but those DLL files need to run there.

If you compile as x86, then the x64 system will run your application in WoW64, and you'll be able to load 32-bit DLL files.

So I think you should choose "Any CPU" if your dependencies can run in either environment, but choose x86 if you have 32-bit dependencies. This article from Microsoft explains this a bit:

/CLRIMAGETYPE (Specify Type of CLR Image)

Incidentally, this other Microsoft documentation agrees that x86 is usually a more portable choice:

Choosing x86 is generally the safest configuration for an app package since it will run on nearly every device. On some devices, an app package with the x86 configuration won't run, such as the Xbox or some IoT Core devices. However, for a PC, an x86 package is the safest choice and has the largest reach for device deployment. A substantial portion of Windows 10 devices continue to run the x86 version of Windows.

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