It makes a difference with array elements.
Consider this example
$a = array('test' => 1);
$a['test'] = NULL;
echo "Key test ", array_key_exists('test', $a)? "exists": "does not exist";
Here, the key 'test' still exists. However, in this example
$a = array('test' => 1);
unset($a['test']);
echo "Key test ", array_key_exists('test', $a)? "exists": "does not exist";
the key no longer exists.