You can create lists and convert them into arrays or you can create array using numpy module. Below are few examples to illustrate the same. Numpy also makes it easier to work with multi-dimensional arrays.
import numpy as np
a = np.array([1, 2, 3, 4])
#For custom inputs
a = np.array([int(x) for x in input().split()])
You can also reshape this array into a 2X2 matrix using reshape function which takes in input as the dimensions of the matrix.
mat = a.reshape(2, 2)