Of the existing IDEs, Ted Neward ranks them this way:
Best: IntelliJ IDEA
Second: Netbeans
Third: Eclipse
He seems to think that Eclipse throws up a lot of "friction"; hard to say what that means.
Edit, years later: After attempting to use Eclipse/Aptana for node development and using JetBrains products for node and ruby development I would absolutely start with IntelliJ IDEA and give that a try for the 30 day trial.