As Nikolai has said you can use the gdb 'set' command to change the value of a variable.
You can also use the 'set' command to change memory locations. eg. Expanding on Nikolai's example:
(gdb) l
6 {
7 int i;
8 struct file *f, *ftmp;
9
(gdb) set variable i = 10
(gdb) p i
$1 = 10
(gdb) p &i
$2 = (int *) 0xbfbb0000
(gdb) set *((int *) 0xbfbb0000) = 20
(gdb) p i
$3 = 20
This should work for any valid pointer, and can be cast to any appropriate data type.