The most complete (and correct) way of doing this would be, I believe:
if (old_key !== new_key) {
Object.defineProperty(o, new_key,
Object.getOwnPropertyDescriptor(o, old_key));
delete o[old_key];
}
This method ensures that the renamed property behaves identically to the original one.
Also, it seems to me that the possibility to wrap this into a function/method and put it into Object.prototype
is irrelevant regarding your question.