[object] Cast object to interface in TypeScript

There's no casting in javascript, so you cannot throw if "casting fails".
Typescript supports casting but that's only for compilation time, and you can do it like this:

const toDo = <IToDoDto> req.body;
// or
const toDo = req.body as IToDoDto;

You can check at runtime if the value is valid and if not throw an error, i.e.:

function isToDoDto(obj: any): obj is IToDoDto {
    return typeof obj.description === "string" && typeof obj.status === "boolean";
}

@Post()
addToDo(@Response() res, @Request() req) {
    if (!isToDoDto(req.body)) {
        throw new Error("invalid request");
    }

    const toDo = req.body as IToDoDto;
    this.toDoService.addToDo(toDo);
    return res.status(HttpStatus.CREATED).end();
}

Edit

As @huyz pointed out, there's no need for the type assertion because isToDoDto is a type guard, so this should be enough:

if (!isToDoDto(req.body)) {
    throw new Error("invalid request");
}

this.toDoService.addToDo(req.body);

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