[.net] Mixed mode assembly is built against version ‘v2.0.50727' of the runtime

I actually had this identical issue with the inverse solution. I had upgraded a .NET project to .NET 4.0 and then reverted back to .NET 3.5. The app.config in my project continued to have the following which was causing the above error in question:

<startup>
  <supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.0"/>
</startup>

The solution to solve the error for this was to revert it back to the proper 2.0 reference as follows:

<startup>
  <supportedRuntime version="v2.0.50727"/>
</startup>

So if a downgrade is producing the above error, you might need to back up the .NET Framework supported version.

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