I will answer the 1 GB version:
There is not enough information in the question, so I will state some assumptions first:
The integer is 32 bits with range -2,147,483,648 to 2,147,483,647.
Pseudo-code:
var bitArray = new bit[4294967296]; // 0.5 GB, initialized to all 0s.
foreach (var number in file) {
bitArray[number + 2147483648] = 1; // Shift all numbers so they start at 0.
}
for (var i = 0; i < 4294967296; i++) {
if (bitArray[i] == 0) {
return i - 2147483648;
}
}