You can use the DATEDIFF function to get the difference in minutes, seconds, days etc.
SELECT DATEDIFF(MINUTE,job_start,job_end)
MINUTE obviously returns the difference in minutes, you can also use DAY, HOUR, SECOND, YEAR (see the books online link for the full list).
If you want to get fancy you can show this differently for example 75 minutes could be displayed like this: 01:15:00:0
Here is the code to do that for both SQL Server 2005 and 2008
-- SQL Server 2005
SELECT CONVERT(VARCHAR(10),DATEADD(MINUTE,DATEDIFF(MINUTE,job_start,job_end),'2011-01-01 00:00:00.000'),114)
-- SQL Server 2008
SELECT CAST(DATEADD(MINUTE,DATEDIFF(MINUTE,job_start,job_end),'2011-01-01 00:00:00.000') AS TIME)