This is for dot net core 2.1 - after a lot of trial and error I finally got this to work flawlessly:
var url = "Hub URL goes here";
var connection = new HubConnectionBuilder()
.WithUrl($"{url}")
.WithAutomaticReconnect() //I don't think this is totally required, but can't hurt either
.Build();
//Start the connection
var t = connection.StartAsync();
//Wait for the connection to complete
t.Wait();
//Make your call - but in this case don't wait for a response
//if your goal is to set it and forget it
await connection.InvokeAsync("SendMessage", "User-Server", "Message from the server");
This code is from your typical SignalR poor man's chat client. The problem that I and what seems like a lot of other people have run into is establishing a connection before attempting to send a message to the hub. This is critical, so it is important to wait for the asynchronous task to complete - which means we are making it synchronous by waiting for the task to complete.