You can do the following:
<form action="/" onsubmit="if(document.getElementById('agree').checked) { return true; } else { alert('please agree'); return false; }">
<input type="checkbox" name="checkbox" value="check" id="agree" />
<input type="submit" name="email_submit" value="submit" />
</form>?
Here is a working demo - http://jsfiddle.net/Ccr2x/