[python] How to add multiple columns to pandas dataframe in one assignment?

If you just want to add empty new columns, reindex will do the job

df
   col_1  col_2
0      0      4
1      1      5
2      2      6
3      3      7

df.reindex(list(df)+['column_new_1', 'column_new_2','column_new_3'], axis=1)
   col_1  col_2  column_new_1  column_new_2  column_new_3
0      0      4           NaN           NaN           NaN
1      1      5           NaN           NaN           NaN
2      2      6           NaN           NaN           NaN
3      3      7           NaN           NaN           NaN

full code example

import numpy as np
import pandas as pd

df = {'col_1': [0, 1, 2, 3],
        'col_2': [4, 5, 6, 7]}
df = pd.DataFrame(df)
print('df',df, sep='\n')
print()
df=df.reindex(list(df)+['column_new_1', 'column_new_2','column_new_3'], axis=1)
print('''df.reindex(list(df)+['column_new_1', 'column_new_2','column_new_3'], axis=1)''',df, sep='\n')

otherwise go for zeros answer with assign

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