Initialize empty frame with column names
import pandas as pd
col_names = ['A', 'B', 'C']
my_df = pd.DataFrame(columns = col_names)
my_df
Add a new record to a frame
my_df.loc[len(my_df)] = [2, 4, 5]
You also might want to pass a dictionary:
my_dic = {'A':2, 'B':4, 'C':5}
my_df.loc[len(my_df)] = my_dic
Append another frame to your existing frame
col_names = ['A', 'B', 'C']
my_df2 = pd.DataFrame(columns = col_names)
my_df = my_df.append(my_df2)
Performance considerations
If you are adding rows inside a loop consider performance issues. For around the first 1000 records "my_df.loc" performance is better, but it gradually becomes slower by increasing the number of records in the loop.
If you plan to do thins inside a big loop (say 10M? records or so), you are better off using a mixture of these two; fill a dataframe with iloc until the size gets around 1000, then append it to the original dataframe, and empty the temp dataframe. This would boost your performance by around 10 times.