Yes, this is possible by using worksheet events:
In the Visual Basic Editor open the worksheet you're interested in (i.e. "BigBoard") by double clicking on the name of the worksheet in the tree at the top left. Place the following code in the module:
Private Sub Worksheet_Change(ByVal Target As Range)
If Intersect(Target, Me.Range("D2")) Is Nothing Then Exit Sub
Application.EnableEvents = False 'to prevent endless loop
On Error Goto Finalize 'to re-enable the events
MsgBox "You changed THE CELL!"
End If
Finalize:
Application.EnableEvents = True
End Sub