In [16]: def shuffle(df, n=1, axis=0):
...: df = df.copy()
...: for _ in range(n):
...: df.apply(np.random.shuffle, axis=axis)
...: return df
...:
In [17]: df = pd.DataFrame({'A':range(10), 'B':range(10)})
In [18]: shuffle(df)
In [19]: df
Out[19]:
A B
0 8 5
1 1 7
2 7 3
3 6 2
4 3 4
5 0 1
6 9 0
7 4 6
8 2 8
9 5 9