Another fairly simple way to go about this is to make a method like this:
def _write_frame_to_new_sheet(path_to_file=None, sheet_name='sheet', data_frame=None):
book = None
try:
book = load_workbook(path_to_file)
except Exception:
logging.debug('Creating new workbook at %s', path_to_file)
with pd.ExcelWriter(path_to_file, engine='openpyxl') as writer:
if book is not None:
writer.book = book
data_frame.to_excel(writer, sheet_name, index=False)
The idea here is to load the workbook at path_to_file if it exists and then append the data_frame as a new sheet with sheet_name. If the workbook does not exist, it is created. It seems that neither openpyxl or xlsxwriter append, so as in the example by @Stefano above, you really have to load and then rewrite to append.