You have to put your main queue dispatching in the block that runs the computation. For example (here I create a dispatch queue and don't use a global one):
dispatch_queue_t queue = dispatch_queue_create("com.example.MyQueue", NULL);
dispatch_async(queue, ^{
// Do some computation here.
// Update UI after computation.
dispatch_async(dispatch_get_main_queue(), ^{
// Update the UI on the main thread.
});
});
Of course, if you create a queue don't forget to dispatch_release
if you're targeting an iOS version before 6.0.