primes = {x for x in range(2, 101) if all(x%y for y in range(2, min(x, 11)))}
I simplified the test a bit - if all(x%y
instead of if not any(not x%y
I also limited y's range; there is no point in testing for divisors > sqrt(x). So max(x) == 100 implies max(y) == 10. For x <= 10, y must also be < x.
pairs = {(x, x+2) for x in primes if x+2 in primes}
Instead of generating pairs of primes and testing them, get one and see if the corresponding higher prime exists.