[python] numpy division with RuntimeWarning: invalid value encountered in double_scalars

You can use np.logaddexp (which implements the idea in @gg349's answer):

In [33]: d = np.array([[1089, 1093]])

In [34]: e = np.array([[1000, 4443]])

In [35]: log_res = np.logaddexp(-3*d[0,0], -3*d[0,1]) - np.logaddexp(-3*e[0,0], -3*e[0,1])

In [36]: log_res
Out[36]: -266.99999385580668

In [37]: res = exp(log_res)

In [38]: res
Out[38]: 1.1050349147204485e-116

Or you can use scipy.special.logsumexp:

In [52]: from scipy.special import logsumexp

In [53]: res = np.exp(logsumexp(-3*d) - logsumexp(-3*e))

In [54]: res
Out[54]: 1.1050349147204485e-116

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