For IIS 8 I did basically the same thing as Monic. Im running my application as its own app pool on an x64 machine 1.In DCOMCNFG, right click on the My Computer and select properties.
2.Choose the COM Securities tab.
3.In Access Permissions, click Edit Defaults and add iis apppool\myapp to it and give it Allow local access permission. Do the same for iis apppool\myapp
4.In launch and Activation Permissions, click Edit Defaults and add iis apppool\myapp to it and give it Local launch and Local Activation permission. Do the same for iis apppool\myapp.
additionally I had to make the folders outlined under C:\Windows\SysWOW64\config\systemprofile\Desktop and give read \ write permissions to iis apppool\myapp also