PYTHONPATH is an environment variable whose value is a list of directories. Once set, it is used by Python to search for imported modules, along with other std. and 3rd-party library directories listed in Python's "sys.path".
As any other environment variables, you can either export it in shell or in ~/.bashrc, see here. You can query os.environ['PYTHONPATH'] for its value in Python as shown below:
$ python3 -c "import os, sys; print(os.environ['PYTHONPATH']); print(sys.path) if 'PYTHONPATH' in sorted(os.environ) else print('PYTHONPATH is not defined')"
IF defined in shell as
$ export PYTHONPATH=$HOME/Documents/DjangoTutorial/mysite
THEN result =>
/home/Documents/DjangoTutorial/mysite
['', '/home/Documents/DjangoTutorial/mysite', '/usr/local/lib/python37.zip', '/usr/local/lib/python3.7', '/usr/local/lib/python3.7/lib-dynload', '/usr/local/lib/python3.7/site-packages']
ELSE result =>
PYTHONPATH is not defined
To set PYTHONPATH to multiple paths, see here.
Note that one can add or delete a search path via sys.path.insert(), del or remove() at run-time, but NOT through os.environ[]. Example:
>>> os.environ['PYTHONPATH']="$HOME/Documents/DjangoTutorial/mysite"
>>> 'PYTHONPATH' in sorted(os.environ)
True
>>> sys.path // but Not there
['', '/usr/local/lib/python37.zip', '/usr/local/lib/python3.7', '/usr/local/lib/python3.7/lib-dynload', '/usr/local/lib/python3.7/site-packages']
>>> sys.path.insert(0,os.environ['PYTHONPATH'])
>>> sys.path // It's there
['$HOME/Documents/DjangoTutorial/mysite', '', '/usr/local/lib/python37.zip', '/usr/local/lib/python3.7', '/usr/local/lib/python3.7/lib-dynload', '/usr/local/lib/python3.7/site-packages']
>>>
In summary, PYTHONPATH is one way of specifying the Python search path(s) for imported modules in sys.path. You can also apply list operations directly to sys.path without the aid of PYTHONPATH.