If you are using the grid or alike component: In XAML, make sure that the elements in the grid have Grid.Row and Grid.Column defined, and ensure tha they don't have margins. If you used designer mode, or Expression Blend, it could have assigned margins relative to the whole grid instead of to particular cells. As for cell sizing, I add an extra cell that fills up the rest of the space:
<Grid.RowDefinitions>
<RowDefinition Height="Auto" />
<RowDefinition Height="Auto" />
<RowDefinition Height="Auto" />
<RowDefinition Height="Auto" />
<RowDefinition Height="Auto" />
<RowDefinition Height="*"/>
</Grid.RowDefinitions>