[c] C Macro definition to determine big endian or little endian machine?

If you want to only rely on the preprocessor, you have to figure out the list of predefined symbols. Preprocessor arithmetics has no concept of addressing.

GCC on Mac defines __LITTLE_ENDIAN__ or __BIG_ENDIAN__

$ gcc -E -dM - < /dev/null |grep ENDIAN
#define __LITTLE_ENDIAN__ 1

Then, you can add more preprocessor conditional directives based on platform detection like #ifdef _WIN32 etc.

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