Perhaps you would accomplish this with something to the effect of
text = raw_input("please give 2 numbers to multiply separated with a comma:")
split_text = text.split(',')
a = int(split_text[0])
b = int(split_text[1])
# The last three lines could be written: a, b = map(int, text.split(','))
# but you may find the code I used a bit easier to understand for now.
if b > 0:
num_times = b
else:
num_times = -b
total = 0
# While loops with counters basically should not be used, so I replaced the loop
# with a for loop. Using a while loop at all is rare.
for i in xrange(num_times):
total += a
# We do this a times, giving us total == a * abs(b)
if b < 0:
# If b is negative, adjust the total to reflect this.
total = -total
print total
or maybe
a * b