You can actually compile and run C code even without the use of nppexec plugins. If you use MingW32 C compiler, use g++ for C++ language and gcc for C language.
Paste this code into the notepad++ run section
cmd /k cd $(CURRENT_DIRECTORY) && gcc $(FILE_NAME) -o $(NAME_PART).exe && $(NAME_PART).exe && pause
It will compile your C code into exe and run it immediately. It's like a build and run feature in CodeBlock. All these are done with some cmd knowledge.
Explanation:
For more info on notepad++ commands, go to
http://docs.notepad-plus-plus.org/index.php/External_Programs