Yes, you can do that.
There are some interesting use cases: Some browsers and plugins parse meta elements and change their behavior for different values.
<meta name="SKYPE_TOOLBAR" content="SKYPE_TOOLBAR_PARSER_COMPATIBLE">
<meta name="format-detection" content="telephone=no">
<meta http-equiv="X-UA-Compatible" content="chrome=1">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
This one can be changed by JavaScript. See: A fix for iPhone viewport scale bug
Some user agents (Opera for example) use the description for bookmarks. You can add personalized content here. Example:
<!DOCTYPE html>
<title>Test</title>
<meta name="description" content="this is old">
<script type='text/javascript' src='http://code.jquery.com/jquery-1.8.2.js'></script>
<button>Change description</button>
<script type='text/javascript'>
$('button').on('click', function() {
// Just replacing the value of the 'content' attribute will not work.
$('meta[name=description]').remove();
$('head').append( '<meta name="description" content="this is new">' );
});
</script>
So, it’s not just about search engines.