With Rake:
rake spec SPEC=path/to/spec.rb
(Credit goes to this answer. Go vote him up.)
EDIT (thanks to @cirosantilli): To run one specific scenario within the spec, you have to supply a regex pattern match that matches the description.
rake spec SPEC=path/to/spec.rb \
SPEC_OPTS="-e \"should be successful and return 3 items\""