You can use the option command:
option(USE_CLANG "build application with clang" OFF) # OFF is the default
and then wrap the clang-compiler settings in if()s:
if(USE_CLANG)
SET (...)
....
endif(USE_CLANG)
This way it is displayed as an cmake option in the gui-configuration tools.
To make it systemwide you can of course use an environment variable as the default value or stay with Ferruccio's answer.