I'd just use zip
:
In [1]: from pandas import *
In [2]: def calculate(x):
...: return x*2, x*3
...:
In [3]: df = DataFrame({'a': [1,2,3], 'b': [2,3,4]})
In [4]: df
Out[4]:
a b
0 1 2
1 2 3
2 3 4
In [5]: df["A1"], df["A2"] = zip(*df["a"].map(calculate))
In [6]: df
Out[6]:
a b A1 A2
0 1 2 2 3
1 2 3 4 6
2 3 4 6 9