I don't think your question is very clear, this code assumes that if you're going to include the -domain parameter, it's always 'named' (i.e. dostuff computername arg2 -domain domain); this also makes the computername parameter mandatory.
Function DoStuff(){
param(
[Parameter(Mandatory=$true)][string]$computername,
[Parameter(Mandatory=$false)][string]$arg2,
[Parameter(Mandatory=$false)][string]$domain
)
if(!($domain)){
$domain = 'domain1'
}
write-host $domain
if($arg2){
write-host "arg2 present... executing script block"
}
else{
write-host "arg2 missing... exiting or whatever"
}
}