Just compare the column with that value:
In [9]: df = pandas.DataFrame([1,2,3,4], columns=["data"])
In [10]: df
Out[10]:
data
0 1
1 2
2 3
3 4
In [11]: df["desired"] = df["data"] > 2.5
In [11]: df
Out[12]:
data desired
0 1 False
1 2 False
2 3 True
3 4 True