You can't update more that one table in a single statement, however the error message you get is because of the aliases, you could try this :
BEGIN TRANSACTION
update A
set A.ORG_NAME = @ORG_NAME
from table1 A inner join table2 B
on B.ORG_ID = A.ORG_ID
and A.ORG_ID = @ORG_ID
update B
set B.REF_NAME = @REF_NAME
from table2 B inner join table1 A
on B.ORG_ID = A.ORG_ID
and A.ORG_ID = @ORG_ID
COMMIT