You can use MultiIndex.droplevel
:
>>> cols = pd.MultiIndex.from_tuples([("a", "b"), ("a", "c")])
>>> df = pd.DataFrame([[1,2], [3,4]], columns=cols)
>>> df
a
b c
0 1 2
1 3 4
[2 rows x 2 columns]
>>> df.columns = df.columns.droplevel()
>>> df
b c
0 1 2
1 3 4
[2 rows x 2 columns]