It's a good idea to apply a recursive definition, as in Vadim Smolyakov's answer, combined with a DP (dynamic programming), but for the latter you may apply the lru_cache decorator from module functools:
import functools
@functools.lru_cache(maxsize = None)
def binom(n,k):
if k == 0: return 1
if n == k: return 1
return binom(n-1,k-1)+binom(n-1,k)