I would like Web applications to not override my default shortcut keys, honestly. Ctrl+S already does something in browsers. Having that change abruptly depending on the site I'm viewing is disruptive and frustrating, not to mention often buggy. I've had sites hijack Ctrl+Tab because it looked the same as Ctrl+I, both ruining my work on the site and preventing me from switching tabs as usual.
If you want shortcut keys, use the accesskey
attribute. Please don't break existing browser functionality.