For file types, where the same file can't be opened in a vertical tab group (for example .vb files) you can
If you save to disk in one instance though, you'll have to reload the file when you switch to the other. Also if you make edits in both instances, you'll have to resolve on the second save. Visual Studio prompts you in both cases with various options. You'll simplify your life a bit if you edit in only the one instance.