I improved on Elad Katz' answer.
Example:
<StackPanel Orientation="Horizontal" foo:Spacing.Horizontal="5">
<Button>Button 1</Button>
<Button>Button 2</Button>
</StackPanel>
<StackPanel Orientation="Vertical" foo:Spacing.Vertical="5">
<Button>Button 1</Button>
<Button>Button 2</Button>
</StackPanel>
<!-- Same as vertical example above -->
<StackPanel Orientation="Vertical" foo:MarginSetter.Margin="0 0 0 5" foo:MarginSetter.LastItemMargin="0">
<Button>Button 1</Button>
<Button>Button 2</Button>
</StackPanel>