UPDATE [TableName]
SET [ColumnName] = Replace([ColumnName], '[StringToRemove]', '[Replacement]')
In your instance it would be
UPDATE [TableName]
SET [ColumnName] = Replace([ColumnName], '[StringToRemove]', '')
Because there is no replacement (you want to get rid of it).
This will run on every row of the specified table. No need for a WHERE clause unless you want to specify only certain rows.