[python] How do I remove a substring from the end of a string in Python?

A broader solution, adding the possibility to replace the suffix (you can remove by replacing with the empty string) and to set the maximum number of replacements:

def replacesuffix(s,old,new='',limit=1):
    """
    String suffix replace; if the string ends with the suffix given by parameter `old`, such suffix is replaced with the string given by parameter `new`. The number of replacements is limited by parameter `limit`, unless `limit` is negative (meaning no limit).

    :param s: the input string
    :param old: the suffix to be replaced
    :param new: the replacement string. Default value the empty string (suffix is removed without replacement).
    :param limit: the maximum number of replacements allowed. Default value 1.
    :returns: the input string with a certain number (depending on parameter `limit`) of the rightmost occurrences of string given by parameter `old` replaced by string given by parameter `new`
    """
    if s[len(s)-len(old):] == old and limit != 0:
        return replacesuffix(s[:len(s)-len(old)],old,new,limit-1) + new
    else:
        return s

In your case, given the default arguments, the desired result is obtained with:

replacesuffix('abcdc.com','.com')
>>> 'abcdc'

Some more general examples:

replacesuffix('whatever-qweqweqwe','qwe','N',2)
>>> 'whatever-qweNN'

replacesuffix('whatever-qweqweqwe','qwe','N',-1)
>>> 'whatever-NNN'

replacesuffix('12.53000','0',' ',-1)
>>> '12.53   '