The following script removes quotation marks only from around the column value if table is called [Messages] and the column is called [Description].
-- If the content is in the form of "anything" (LIKE '"%"')
-- Then take the whole text without the first and last characters
-- (from the 2nd character and the LEN([Description]) - 2th character)
UPDATE [Messages]
SET [Description] = SUBSTRING([Description], 2, LEN([Description]) - 2)
WHERE [Description] LIKE '"%"'