A solution combining find and replace methods in a single line if statement could be:
```python
my_var = "stackoverflaw"
my_new_var = my_var.replace('a', 'o', 1) if my_var.find('s') != -1 else my_var
print(f"my_var = {my_var}") # my_var = stackoverflaw
print(f"my_new_var = {my_new_var}") # my_new_var = stackoverflow
```