Use the onchange event in HTML/standard JavaScript.
In jQuery that is the change() event. For example:
$('element').change(function() { // do something } );
EDIT
After reading some comments, what about:
$(function() {
var content = $('#myContent').val();
$('#myContent').keyup(function() {
if ($('#myContent').val() != content) {
content = $('#myContent').val();
alert('Content has been changed');
}
});
});